Edward Smythe (died 1714), was MP for Leicestershire.

Edward Smythe may also refer to:

• Sir Edward Smythe, 4th Baronet (1719–1784), of the Smythe Baronets
• Sir Edward Smythe, 5th Baronet (1758–1811), of the Smythe Baronets
• Sir Edward Smythe, 6th Baronet (1787–1856), of the Smythe Baronets
• Sir Edward Smythe, 9th Baronet (1869–1942), of the Smythe Baronets

• Edward Smyth (disambiguation)
• Edward Smith (disambiguation)

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