Effie is a feminine given name, sometimes a short form (hypocorism) of Efthymia (Greek: Ευθυμία), Eftychia (Greek: Ευτυχία), or Euphemia (Greek: Ευφημία). Notable people with the name include:

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• Effie Bancroft (1840–1921), English actress and theatre manager
• Effie Boggess (1927-2021), American politician
• Effie Cardale (1873–1960), New Zealand community and welfare worker
• Effie Cherry (1869–1944), American performer, part of the Cherry Sisters touring vaudeville act
• Effie Crockett (1857–1940), American actress
• Euphemia Effie Ellsler (1855–1942), American stage and film actress
• Euphemia Effie Germon (1845–1914), American stage actress
• Euphemia Effie Gray (1828–1897), Scottish model, married to John Ruskin and John Everett Millais
• Effie Hotchkiss, American pioneering motorcyclist in 1915
• Effie Mae Martin Howard, real name of Rosie Lee Tompkins (1936–2006), African-American quiltmaker
• Effie McCollum Jones (1869–1952), American Universalist minister and suffragette
• Effie Neal Jones (1919–2002), American civil rights activist
• Effie Mona Mack (1888–1969), American historian
• Effie Pedaliu, British historian
• Effie Louise Power (1873–1969), American children's librarian and author
• Euphemia Effie Newbigging Richardson (1849–1928), New Zealand landowner and litigant
• Effie Robinson (1920-2003), American social worker and public housing director
• Effie Hoffman Rogers (1855-1918), American educator
• Effie Adelaide Rowlands (1859–1936), usual pen name of Australian-born British novelist Effie Albanesi
• Effie Shannon (1867–1954), American stage and silent screen actress
• Effie Smith (1914-1977), American jazz and blues singer and comedian
• Effie Anderson Smith (1869–1955), American painter
• Effie Waller Smith (1879–1960), African-American poet
• Effie A. Southworth (1860–1947), American botanist and mycologist
• Effie Wilder (1909–2007), American novelist

• Elisha Effie Norton (1873–1950), American Major League Baseball pitcher

• Effie Clinker, a radio character developed by Edgar Bergen
• Effie Deans, in Sir Walter Scott's 1818 novel The Heart of Midlothian
• Mrs Euphegenia "Effie" Doubtfire, a disguised character in the 1993 film Mrs. Doubtfire, played by Robin Williams
• Effie Grant Munro, in the Sherlock Holmes story "The Adventure of the Yellow Face"
• Effie Harrison, on the British soap opera Emmerdale
• Effie Kaligaris, in The Sisterhood of the Traveling Pants novels
• Effie Newsome / Effie Crabtree, in the Canadian series Murdoch Mysteries, played by Canadian actress Clare McConnell since 2018
• Effie Perine, Sam Spade's secretary in the novel The Maltese Falcon and its film adaptations
• Effie Rawlinson - character in The Case of the Late Pig; an Albert Campion mystery by Margery Allingham

• Effie Spicer, on the British soap opera Coronation Street from 1968 to 1969
• Effie Stephanidis, comedic television character, played by Australian actress Mary Coustas
• Effie Trinket, in the book series The Hunger Games
• Effie White, one of the lead characters in the Broadway musical Dreamgirls
• Effie, in the video game Fire Emblem Fates
• Effie, a non playable character in Street Fighter III

• Effie M. Morrissey, a schooner used for arctic research
• Effi (disambiguation)
• Effy Stonem, a character on Skins
• Eftychia, a Greek given name
• Euphemia (disambiguation)

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