Epsilon-Amanitin
ε-Amanitin
Cyclic peptide part of a group of toxins present in Amanita mushrooms
ε-Amanitin (epsilon-Amanitin) is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus Amanita. The oral LD50 of ε-amanitin is approximately 0.1 mg/kg.
Quick Facts Identifiers, Properties ...
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C39H53N9O14S | |
Molar mass | 903.96 g/mol |
Appearance | Colorless, crystalline solid |
Soluble | |
Solubility in ethanol and methanol | Soluble |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Like other amatoxins, ε-amanitin is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]
- M. Cochet-Meillhac; Chambon P. (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim Biophys Acta. 353 (2): 160–184. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
- Amatoxins REVISED Archived 2009-01-13 at the Wayback Machine
- Poisonous Mushrooms (German)