Ernest Reginald Nickerson (September 27, 1876 – May 28, 1956) was a merchant and political figure in Nova Scotia, Canada. He represented Shelburne County in the Nova Scotia House of Assembly from 1925 to 1928 as an Independent Conservative member.

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He was born in Shag Harbour, Shelburne County, Nova Scotia, the son of Thomas Nickerson and Mary Crowell. In 1901, Nickerson married Ada M. Reid. He served as a member of the municipal council for Barrington township. Nickerson was sergeant-at-arms for the provincial legislature from 1928 to 1933. He was a prominent member of the Sons of Temperance. Nickerson moved from Shag Harbour to Halifax in 1928. He was a salesman for gas and oil burners and an insurance agent there. He died in Halifax at the age of 79.