Erythromycin_3''-O-methyltransferase

Erythromycin 3''-O-methyltransferase

Erythromycin 3''-O-methyltransferase

Enzyme

Erythromycin 3''-O-methyltransferase (EC 2.1.1.254, EryG) is an enzyme with systematic name S-adenosyl-L-methionine:erythromycin C 3''-O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + erythromycin C S-adenosyl-L-homocysteine + erythromycin A
(2) S-adenosyl-L-methionine + erythromycin D S-adenosyl-L-homocysteine + erythromycin B
Quick Facts Identifiers, EC no. ...

The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C.

References

  1. [1]
    Paulus TJ, Tuan JS, Luebke VE, Maine GT, DeWitt JP, Katz L (May 1990). "Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli". Journal of Bacteriology. 172 (5): 2541–6. doi:10.1128/jb.172.5.2541-2546.1990. PMC 208895. PMID 2185226.
  2. [2]
    Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L (October 1997). "Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production". Microbiology. 143 (10): 3251–62. doi:10.1099/00221287-143-10-3251. PMID 9353926.


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