The First Wilson Ministry was the 10th Ministry of the Government of Western Australia and was led by Ministerialist Premier Frank Wilson. It succeeded the Moore Ministry on 16 September 1910 after Sir Newton Moore resigned to accept an appointment as Agent-General for Western Australia in London. The ministry was followed by the Scaddan Ministry on 7 October 1911 after the Ministerialists lost government at the state election held four days earlier.

On 16 September 1910, the Governor, Rt Hon Baron Gerald Strickland, designated 6 principal executive offices of the Government under section 43(2) of the Constitution Acts Amendment Act 1899. The following ministers were then appointed to the positions, and served until the end of the Ministry on 7 October 1911.

• Black, David; Bolton, Geoffrey (2001). Biographical Register of Members of the Parliament of Western Australia, Volume One, 1870–1930 (Revised ed.). Parliament House: Parliament of Western Australia. ISBN 0730738140.
• de Garis, Brian (1991). "Self-Government and Political Parties". In Black, David (ed.). The House on the Hill: A History of the Parliament of Western Australia 1832–1990. Perth, Western Australia: Parliament of Western Australia. ISBN 0730939839.
• Bolton, Geoffrey; Mozley, Ann (1961). The Western Australian Legislature, 1870-1930. Canberra: Australian National University. (no ISBN)