The flexor digitorum profundus is a muscle in the forearm of humans that flexes the fingers (also known as digits). It is considered an extrinsic hand muscle because it acts on the hand while its muscle belly is located in the forearm.

Together the flexor pollicis longus, pronator quadratus, and flexor digitorum profundus form the deep layer of ventral forearm muscles.^[1] The muscle is named from Latin 'deep bender of the fingers'.

Flexor digitorum profundus originates in the upper 3/4 of the anterior and medial surfaces of the ulna, interosseous membrane and deep fascia of the forearm. The muscle fans out into four tendons (one to each of the second to fifth fingers) to the palmar base of the distal phalanx.^{[citation needed]}

Along with the flexor digitorum superficialis, it has long tendons that run down the arm and through the carpal tunnel and attach to the palmar side of the phalanges of the fingers.^{[citation needed]}

Flexor digitorum profundus lies deep to the superficialis, but it attaches more distally. Therefore, profundus's tendons go through the tendons of superficialis, and end up attaching to the distal phalanx. For this reason profundus is also called the perforating muscle.^[1]

The lumbricals of the hand arise from the radial side of its tendons.^[1]

Flexor digitorum profundus is a flexor of the wrist (midcarpal), metacarpophalangeal and interphalangeal joints.^[1] The lumbricals, intrinsic muscles of the hand, attach to the tendon of flexor digitorum profundus. Thus, the flexor muscle is used to aid the lumbrical muscles in their role as extensors of the interphalangeal joints. As the lumbrical muscles originate on the palmar side of the hand and attach on the dorsal aponeurosis, power is transferred from the flexor digitorum profundus muscle to fully extend the fingers as well as flex the metacarpophalangeal joints.^{[citation needed]}

The tension generated by flexor digitorum profundus at the more distal joints is determined by wrist position. Flexion of the wrist causes muscle shortening at that point, reducing tension that can be generated more distally. Fingers cannot be fully flexed if the wrist is fully flexed.^[8]

In many primates, the FDP is fused with the flexor pollicis longus (FPL). In great apes the belly of the FDP has a separate tendon for the FDP. In lesser apes, both muscles have separate bellies in the forearm, but in Old World monkeys they separate in the carpal tunnel. The lack of differentiation in the FDP musculature in baboons makes it unlikely that this monkey can control individual fingers independently. ^[9]

• Jersey finger, a rupture of the tendon connecting to the muscle