Fosfluconazole

Fosfluconazole

Fosfluconazole

Chemical compound

Fosfluconazole (INNTooltip International Nonproprietary Name) is a water-soluble phosphate prodrug of fluconazole[1] — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.[2]

Quick Facts Clinical data, AHFS/Drugs.com ...

The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).[3]

References

  1. [1]
    Bentley A, Butters M, Green SP, Learmonth WJ, MacRae JA, Morland MC, O'Conno G, Skuse J (2002). "The Discovery and Process Development of a Commercial Route to the Water Soluble Prodrug, Fosfluconazole". Organic Process Research & Development. 6 (2): 109–112. doi:10.1021/op010064+. ISSN 1083-6160.
  2. [2]
    Takahashi D, Nakamura T, Shigematsu R, Matsui M, Araki S, Kubo K, et al. (2009-05-25). "Fosfluconazole for antifungal prophylaxis in very low birth weight infants". International Journal of Pediatrics. 2009 (2009): 274768. doi:10.1155/2009/274768. PMC 2778452. PMID 19946419.
  3. [3]
    Lee CC, Schrier WH, Nagyvary J (January 1979). "The enzymatic hydrolysis of the phosphate ester bond in some thionucleotides". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 561 (1): 223–231. doi:10.1016/0005-2787(79)90505-7. PMID 84687.
Stub icon

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Fosfluconazole, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.