Francesco II may refer to:

• Francesco II Ordelaffi (1300–1386)
• Francesco II of Lesbos (c. 1365 – 1403/1404)
• Francesco II Acciaioli (died 1460), last Duke of Athens
• Francesco II Gonzaga, Marquess of Mantua (1466–1519), ruler of the Italian city of Mantua
• Francesco II Sforza (1495–1535), Duke of Milan from 1521 until his death
• Francesco II d'Este, Duke of Modena (1660–1694), Duke of Modena and Reggio from 1662 to 1694
• Francesco II of the Two Sicilies (1836–1894)

This disambiguation page lists articles about people with the same name.
If an internal link led you here, you may wish to change the link to point directly to the intended article.