|Date of birth||24 July 2000|
|Place of birth||Rome, Italy|
|Height||1.81 m (5 ft 11 in)|
|2019–2020||→ Carrarese (loan)||13||(1)|
|2020||→ Pontedera (loan)||4||(0)|
|2020–2021||→ Feralpisalò (loan)||8||(0)|
|2021||→ Pro Vercelli (loan)||9||(0)|
* Senior club appearances and goals counted for the domestic league only and correct as of 1 July 2021|
‡ National team caps and goals correct as of 7 February 2018
On 31 August 2017, he joined Serie A club Napoli. For the next two seasons, he played for the club's Under-19 squad in Campionato Primavera 1 and UEFA Youth League, without any call-ups to the senior squad.
Loan to Carrarese
He made his professional Serie C debut for Carrarese on 24 August 2019 in a game against Pontedera, playing the whole game. He finished the loan with 13 league appearances, 8 of them as a starter, and 1 goal.
Loan to Pontedera
Loan to Feralpisalò
On 17 September 2020, he joined Feralpisalò on loan.
Loan to Pro Vercelli
On 8 January 2021, he joined Pro Vercelli on loan.
He first represented his country with the Under-18 squad on 7 February 2018 in a friendly against France.
- "Carpi v Ternana game report". Soccerway. 10 December 2016.
- "Napoli, arrive Mezzoni from Carpi and Sgarbi from Sud Tirol" (Press release) (in Italian). Napoli. 31 August 2017.
- "Mezzoni alla Carrarese, uno sprinter sulla fascia destra azzurra" (Press release) (in Italian). Carrarese. 1 August 2019.
- "Pontedera v Carrarese game report". Soccerway. 24 August 2019.
- "La società U.S Città di Pontedera comunica l'arrivo in maglia granata di Francesco Mezzoni" (in Italian). Pontedera. 30 January 2020.
- "Feralpisalò: Arriva Francesco Mezzoni in prestito dal Napoli" (in Italian). Il Napoli Online. 17 September 2020.
- "BENVENUTO FRANCESCO MEZZONI" (in Italian). Pro Vercelli. 8 January 2021.
- "France U18 v Italy U18 game report" (in Italian). Italian Football Federation. 7 February 2018.