Francesco Onofrio Odierna (born 1644) was a Roman Catholic prelate who served as Titular Bishop of Berytus (1727), Bishop of Valva e Sulmona (1717–1727) and Bishop of Bitetto (1669–1717).^{[2][3][4][5][6][7]}

Francesco Onofrio Odierna (also known as Hodierna) was born in Naples, Italy in 1644.^[1] His father was the jurist Giovan Battista Odierna. He was ordained a deacon on 20 January 1669 and ordained a priest on 27 January 1669.^[2] On 24 April 1684, he was appointed during the papacy of Pope Innocent XI as Bishop of Bitetto.^[2] On 4 January 1717, he was appointed during the papacy of Pope Clement XI as Bishop of Valva e Sulmona.^[2] He served as Bishop of Valva e Sulmona until his resignation on 6 March 1727.^[2] On 17 March 1727, he was appointed during the papacy of Pope Benedict XIII as Titular Bishop of Berytus.^[2] He died in 1736.^[8]

While bishop, he was the principal co-consecrator of:^[2]

• Giovanni Battista de Belli, Bishop of Telese o Cerreto Sannita (1684);
• Fulvio Crivelli (Cribelli), Bishop of Tricarico (1684);
• Antonio Polcenigo, Bishop of Feltre (1684);
• Domenico Minio, Bishop of Caorle (1684);
• Baldassare de Benavente, Bishop of Potenza (1686); and
• Filippo Massarenghi, Bishop of Bitonto (1686).