GC2, GC-II, or variant may refer to:

• Autopista GC-2, a highway in Gran Canaria
• NGC 7, a.k.a. GC 2, a spiral galaxy in Sculptor Constellation
• Second Geneva Convention, a.k.a. GCII, one of the Geneva Conventions
• Groupe de Chasse II (GC II), a fighter group of the French Air Force, see Groupe de Chasse
• Galactic Civilizations II: Dread Lords, a turn-based strategy game
• Ground Control II: Operation Exodus, a real-time tactics game

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