The IndyCar Series has held racing events at Texas Motor Speedway, near Fort Worth, Texas, since 1997. The races have had a variety of different title sponsors and distances over the years, and therefore the Texas round has changed names frequently. The latest event, held in 2023, was called the PPG 375.

The first Championship/Indy car races in the Dallas/Fort Worth area took place at Arlington Downs Raceway in nearby Arlington, Texas. AAA sanctioned five races from 1947 to 1950. USAC sanctioned ten Championship car events at Texas World Speedway in College Station, Texas. The race was discontinued when the track closed in 1981.

In 1997, the IndyCar Series debuted at Texas Motor Speedway. The event was traditionally a single race held on a Saturday night in early June. Twice, in 2011 and 2021, the series has held twin races at the track. From 1997 until 2005, it served as the first race after the Indianapolis 500. It resumed this place in 2010 and in 2011. In 2020, it served as the first race of the season due to the COVID-19 pandemic. In 2021 the event moved to the first weekend in May, and in 2022 the event was moved to a March date.

In September 2023, it was announced that Texas Motor Speedway was not on the 2024 IndyCar Series schedule.

From 1998 to 2004, a second 500 km IndyCar Series race was held at the track in the fall. It served as the IndyCar Series' season finale for each of its runnings.

In 2003, Gil de Ferran was leading on lap 187 when Kenny Bräck crashed on the backstretch. The massive accident seriously injured Bräck, and he raced only limitedly afterwards. With the race winding down under caution, and with cleanup still ongoing, officials stopped the race after 195 laps when it was clear they would not have time to go back to green. de Ferran was declared the winner in what was his final race in IndyCar (he had announced his retirement during the season).

When the track opened, the one-lap distance was measured as 1.5 miles (2.4 km). IndyCar Series races were originally 208 laps (312 mi/500 km) long. In 2001, timing and scoring officials revised the measurement as 1.455 miles (2.342 km), and the races were changed to an even 200 laps (291 mi/468.319 km). In 2007, the race was lengthened to 228 laps in an effort to create a longer product for time value purposes. Using the traditional 1.5-mile (2.4 km) measurement, the race became 342 miles (550.4 km). However, official IndyCar timing and scoring maintained the 1.455-mile (2.342 km) measurement, and the race was officially 331.74 miles (533.88 km). In 2014, the race was extended to 600 kilometers.^[1] After revamping the oval track in 2016, the new one lap measurement is 1.44 miles for lap speed calculations.^[2]

In addition, the start time was moved to 9:00 p.m. CDT (10:00 p.m. EDT) so the event would take place almost entirely under the lights, rather than in the mid-summer twilight.^[3]

The race was slightly shortened to 300 miles and 200 laps in 2020, due to COVID-19 pandemic protocols that used same-day practice and qualifying for the event. The 2020 Genesys 300 was the first IndyCar event since a hiatus due to the pandemic.^[4] The 300-mile distance will also be used for 2021.^[5]

CART scheduled a race at the track for April 29, 2001. Following practice and qualifying, however, the race was cancelled "due to irresolvable concerns over the physical demands placed on the drivers at race speeds."^[9] All but four drivers reported they had experienced vertigo-like symptoms due to lateral g-forces from driving in excess of 230 mph (370 km/h) on the steep 24 degree banks.

The Dayton Indy Lights race was completed with two cautions.

Starting in 2019 Texas Motor Speedway began to apply PJ1 TrackBite on the high portion of the banking on the track. This was done for NASCAR, who runs multiple events at the speedway and whose cars benefit from the addition of the substance on the track. For IndyCars however the application of PJ1 has created numerous problems. IndyCar's harder tire compounds struggle to grab onto to the PJ1, which combined with the lower downforce levels of IndyCar's current aerodynamic package has led many drivers to compare driving on the substance to driving on ice.^[10] Because the drivers avoid the PJ1 coated sections of the banking so called "marbles" from the worn tires are thrown by the cars onto the PJ1 coated surface, exacerbating the problem of low grip on those banks of the track. This in turn makes Texas Motor Speedway a one groove racetrack for the IndyCars and has resulted several accidents in the races run at the speedway since the PJ1 was first applied. IndyCar drivers have become very critical of the track at Texas in recent years and have complained that the PJ1 results in racing that is both uninteresting and unsafe at the same time.^[11][12]

For 2022 IndyCar and Dallara unveiled bargeboards for use at Texas in an attempt to open up the portions of the track coated with PJ1 to the drivers. The bargeboards are expected to add an additional 200 pounds of downforce on top of the UAK18 superspeedway aero kit and will be optional for teams to use during both qualifying and the race.^[13] Teams opted not to run the bargeboards in 2022. IndyCar mandated the use of the bargeboards in 2023.