Giannozzo Manetti (1396–1459) was an Italian politician and diplomat from Florence, who was also a humanist scholar of the early Italian Renaissance and an anti-Semitic polemicist.^[1]

Manetti was the son of a wealthy merchant. His public career began in 1428. He participated in municipal government as a member of the advisory council, as an ambassador, and in various gubernatorial positions in the city. Manetti was an eyewitness of the dedication of Santa Maria del Fiore on 25 March 1436, of which he left a record, the Oratio de Secularibus et Pontificalibus Pompis in Consecratione Basilicae Florentinae. His views on Florentine relations with Venice proved unpopular among the ruling class, and he put himself into voluntary exile, spending the last years of his life in Naples.^[2]

He was a Latinist and a translator of Greek; he also studied Hebrew so that he could read the Hebrew Bible and the rabbinic commentaries, not to seek tolerance but to attack Jews with their own sources.^[1] These readings convinced him that the Bible needed translation anew from the early manuscripts. After his death, Manetti's sizable library found its way into the Biblioteca Vaticana.

As an author, Manetti's style was an imitation of Cicero. He is now remembered principally as the author of De dignitate et excellentia hominis libri IV ("On the Dignity and Excellence of Man in Four Books"), completed in manuscript in 1452 or 1453. It was a response to Pope Innocent III's De Miseria Condicionis Humane. His Pistoiese History, composed in 1446–47, was the first contemporary critical response to Leonardo Bruni's innovative and monumental History of the Florentine People. He also wrote a commentary on Aristotle and biographies of Dante Alighieri, Giovanni Boccaccio, Pope Nicholas V, Francesco Petrarca, Seneca, and Socrates.

Manetti's circle of humanist intellectuals included Carlo Marsuppini, Poggio Bracciolini, Leonardo Bruni, Francesco Filelfo, Niccolò de' Niccoli, Palla Strozzi, and Lorenzo Valla.

• Apologeticus, as A Translator's Defense ed. Myron McShane, Translated into English by Mark Young. Harvard University Press. 2015. [A defense of the study of Hebrew]. ISBN 978-0674088658.
• Biographical Writings, ed. Stefano U. Baldassarri and Rolf Bagemihl, I Tatti Renaissance Library, Cambridge, Mass., Harvard University Press, 2003. ISBN 978-0674011342.
• De dignitate et excellentia hominis, ed. Elizabeth R. Leonard, Padua, Editrice Antenore, 1974. ISBN 978-8884551436.
• De terremotu, ed. Daniela Pagliara, Florence, SISMEL-Edizioni del Galluzzo, 2012. ISBN 978-88-8450-492-0.
• De vita ac gestis Nicolai quinti summi pontificis, ed. Anna Modigliani, Fonti per la storia d'Italia, Rome, Istituto storico italiano per il Medio Evo, 2005. ISBN 8889190108.
• Historia Pistoriensis, critical edition by Stefano Ugo Baldassarri and Benedetta Aldi, historical commentary by William J. Connell, Edizione Nazionale dei Testi della Storiografia Umanistica, Florence, SISMEL-Edizioni del Galluzzo, 2011. ISBN 978-8884504425.
• On the Dignity of Man, in Two Views of Man: Pope Innocent III - On the Misery of Man ; Giannozzo Manetti - On the Dignity of Man, ed. and trans. Bernard Murchland, New York, Ungar, [1966].
• Un episodio del proto-humanismo español: tres opúsculos de Nuño de Guzmán y Giannozzo Manetti, ed. Jeremy N. H. Lawrence, Salamanca, Biblioteca española del Siglo XV-Diputaciòn de Salamanca, 1989.
• Vita Socratis et Senecae, ed. Alfonso De Petris, Florence: Leo S. Olschki, 1979.
• On Human Worth and Excellence, edited by Brian P. Copenhaver, Harvard University Press, 2018 (The I Tatti Renaissance Library, 85).