The title of Grand Duke of Tuscany was created on August 27, 1569 by a papal bull of Pope Pius V to Cosimo I de' Medici, member of the illustrious House of Medici. His coronation took place in Rome on March 5, 1570, by the hands of the Pope himself.^[1]

Cosimo's family, the Medici dynasty, had been ruling the Florentine Republic, the predecessor of the Grand Duchy of Tuscany, since 1434, first as Lords of Florence and later as Dukes.^[2] The title of Grand Duke, was in fact the second title of recognition within the Tuscan politics given by a Pope to the Medici family, the first being that of Duke of the Florentine Republic, created by Pope Clement VII in 1532.^[3][4]

The official residence of the Grand Dukes was the Palazzo Pitti in Florence, bought by the Medici in 1549.^[5]

Margraves reigned in the 9th century when the region was part of the Margraviate of Tuscany. Beginning in the 11th century, the region was fully divided into several independent cities, which included Pisa, Florence, Siena, Lucca, Arezzo among others. However, with the territorial expansion of Florence, Tuscany began to "come together" again under one single leadership. This situation became even clearer with the creation of the Grand Duchy of Tuscany in 1569. Over the years, the Grand duchy managed to absorb practically the entire region of present-day Tuscany, until its own final annexation to the Kingdom of Italy.^[6]

The Grand Duchy of Tuscany was the first period after centuries of political divisions, when most of the region was under the rule of a single leader. The Grand Duchy's territory comprised almost the entire region of present-day Tuscany, with the exception of the Republic of Lucca, the Principality of Piombino, the Duchy of Massa and Carrara and the State of the Presidi.^[7]

Period that the Bourbon-Parma were placed as "Kings" by Napoleon in the Kingdom of Etruria. The Kingdom was a creation of Napoleon to replace the Grand Duchy of Tuscany, comprising a large part of modern Tuscany.^[8]

Tuscany was annexed by France, 1807–1814. Napoleon's sister Elisa Bonaparte was given the honorary title of Grand Duchess of Tuscany, but did not actually rule over the region.

Leopoldo II was driven from Tuscany by revolution from 21 February to 12 April 1849, and again on 27 April 1859. He abdicated in favor of his son, Ferdinando IV, on 21 July 1859, but Ferdinando IV was never recognized in Tuscany, and was deposed by the provisional government on 16 August. Tuscany was annexed by Piedmont-Sardinia on 22 March 1860.^[9]

• March of Tuscany § Margraves of Tuscany, 812–1197
• History of Tuscany § Republican governments, c. 1000–1805
• List of heads of state of Florence (1434 to 1569)
• List of Tuscan consorts
• Grand Duchy of Tuscany
• History of Tuscany