The Great Plains is a large, flat region of land in North America.

Great Plains may also refer to:

• Great Plains (Ohio band), a 1980s folk pop band
• Great Plains (Tennessee band), an American country music group
• "The Great Plains", a song by Scale the Summit from the album Carving Desert Canyons
• Great Plains Airlines, a defunct airline
• Great Hungarian Plain, a large plain spanning several countries in Eastern Europe
• Great Plains Software, a software company from Fargo, North Dakota that was acquired by Microsoft
• Microsoft Great Plains, accounting software now incorporated into Microsoft Dynamics GP
• Great Plains clothing brand, part of French Connection group
• Great Plains Aircraft Supply Company, an American company

This disambiguation page lists articles associated with the title Great Plains.
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