The Great Southern Automobile Company was the first automobile manufacturer in the central South.^[1] It was incorporated in Birmingham, Alabama, in 1909^[1][2] and manufactured automobiles, automobile parts, and buses from its plant in Ensley, where it also maintained a repair department. Its founding officers were Eugene F. Enslen, president; Ike Adler, vice-president; John Kyser, secretary and treasurer; and Eugene F. Enslen, Jr., general manager.^[2]

In early 1910, it announced a Model "50" touring car with a wheel base of 124 inches, a 5.25x6 inches bore and stroke engine, capable of 60 bhp.^[3]

In 1912, it opened salesrooms in the Empire Building, then the tallest building in Birmingham. The manager was W. O. Fields.^[4]

In 1913, it was manufacturing two models:^[5]

• Great Southern 30, available in two-seater roadster and five-seater touring bodies for $1400.
• Great Southern 51, available in a six-seater touring body for $2100.

In 1914, it dropped the Great Southern 30, and concentrated on the manufacture of just the Great Southern 50 chassis, formerly titled the Great Southern 51.^[6] The new 50 model was a seven passenger touring body.

By 1915, it was manufacturing a chassis and body for a "one-man, pay-enter" motor bus that was 22 feet long, 8 feet 9 inches high, 7 feet 6 inches wide, rated at 2.25 tons capacity, and could carry 25 passengers.^[7]

The company went bankrupt in 1917.^[8] Alabama's other pre-1950 car manufactures include Preston Motor's Premocar in Birmingham and Keller in Huntsville.