Grigore Cazacliu (January 25, 1892 – December 27, 1959) was a Romanian politician from Bessarabia, and a member of Sfatul Țării.

He was born in Cușelăuca, Soroksky Uyezd, Bessarabia Governorate. Cazacliu served as Member of the Sfatul Țării (the Parliament of Bessarabia) in 1917–1918, a student at the time. The Cazacliu family played an important role in the Great Union; Ion Cazacliu was Grigore's uncle, and Vladimir Cazacliu was his brother. Vladimir and Grigore Cazacliu were the sons of Alexandru and Evdochia Cazacliu; they also had a brother, Ioan, and a sister, Ludmila.

Grigore Cazacliu died in Bucharest, at age 67.

• Sfatul Țării, December 10, 1918; Grigore Cazacliu is in the middle, standing behind the seated row
• Moldovan stamp, 1998

• Gheorghe E. Cojocaru, Sfatul Țării: itinerar, Civitas, Chișinău, 1998, ISBN 9975-936-20-2
• Mihai Tașcă, Sfatul Țării și actualele autorități locale, Timpul de dimineață, no. 114 (849), June 27, 2008 (page 16)

• Arhiva pentru Sfatul Țării
• Deputații Sfatului Țării și Lavrenti Beria