Hayley Arceneaux (born December 4, 1991) is a St. Jude Children's Research Hospital physician assistant and commercial astronaut. She joined billionaire Jared Isaacman on SpaceX's first private spaceflight Inspiration4, which launched on September 16, 2021, 00:02:56 UTC, and successfully water-landed local-time on Saturday, September 18.^[4] Arceneaux became the first human in space with a prosthetic leg bone after surviving bone cancer.^[5] At age 29, Arceneaux was the youngest American to travel to space, surpassed a few months later by 23 year old Cameron Bess aboard Blue Origin NS-19.^[6] Arceneaux remains the youngest American to have orbited the Earth.

Arceneaux was raised in St. Francisville, Louisiana. Her father, Howard Stanford Arceneaux, died July 5, 2018, at the age of 60 years old.^[7] Her brother, Hayden, and sister-in-law, Liz Suttles, are aerospace engineers.^[3]

When she was 10 years old,^[8] her left knee began to ache. Her doctor thought it was just a sprain, but a few months later, tests revealed she had osteosarcoma, a type of bone cancer. Her family turned to St. Jude Children's Research Hospital for her treatment and care, which included around a dozen rounds of chemotherapy, a limb-preservation surgery with knee replacement and placement of a titanium rod in her left thigh bone along with associated physical therapy.^[1] The experience inspired her to want to work with other cancer patients at St. Jude, which she does as a physician assistant working with leukemia and lymphoma patients.^[8]

Arceneaux graduated from St. Joseph's Academy in Baton Rouge, Louisiana, and obtained an undergraduate degree in Spanish in 2014. She obtained her Physician Assistant (PA) degree in 2016 from LSU Health in Shreveport, Louisiana.^[8][9]

• 2003 Louisiana Young Heroes.^[14]

• Wild Ride: A Memoir of I.V. Drips and Rocket Ships - by Hayley Arceneaux - 2022 - ISBN 0-59-344384-5