Hexaprenyl-diphosphate_synthase_((2E,6E)-farnesyl-diphosphate_specific)

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

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Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate 3 diphosphate + all-trans-hexaprenyl diphosphate
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The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.

References

  1. [1]
    Fujii H, Koyama T, Ogura K (December 1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". The Journal of Biological Chemistry. 257 (24): 14610–2. doi:10.1016/S0021-9258(18)33320-9. PMID 7174655.
  2. [2]
    Shimizu N, Koyama T, Ogura K (March 1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". Journal of Bacteriology. 180 (6): 1578–81. doi:10.1128/JB.180.6.1578-1581.1998. PMC 107062. PMID 9515931.
  3. [3]
    Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T (August 2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorganic & Medicinal Chemistry Letters. 11 (16): 2157–9. doi:10.1016/S0960-894X(01)00391-2. PMID 11514159.
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