High-mannose-oligosaccharide_b-1,4-N-acetylglucosaminyltransferase

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase

Class of enzymes

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.197), uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase, acetylglucosamine-oligosaccharide acetylglucosaminyltransferase, UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide 4-beta-N-acetylglucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-(1->6) to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum
Quick Facts Identifiers, EC no. ...

The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by alpha-1,3 and alpha-1,6 links.

References

  1. [1]
    Sharkey DJ, Kornfeld R (June 1989). "Identification of an N-acetylglucosaminyltransferase in Dictyostelium discoideum that transfers an "intersecting" N-acetylglucosamine residue to high mannose oligosaccharides". The Journal of Biological Chemistry. 264 (18): 10411–9. PMID 2525124.
Share this article:

This article uses material from the Wikipedia article High-mannose-oligosaccharide_b-1,4-N-acetylglucosaminyltransferase, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.