House of Splendid Isolation is a 1994 novel by Irish novelist Edna O'Brien. The novel depicts the relations of an Irish Republican Army^[which?] terrorist and his hostage, an elderly woman.^[1] The novel brings elements of the thriller genre to O'Brien's ongoing explorations of Irish society.^[1] It is based on the life of Dominic McGlinchy, whom O'Brien interviewed while incarcerated in Portlaoise Prison.

The New York Times gave a mediocre review calling the novel both "a brave book, and if it does not altogether succeed, [and an] attempt nonetheless [that] merits praise."^[1] The review notes that the novel is a "dramatic departure" from O'Brien's typical novels, and in that context of experiment "we see her audacity fail and her elegant prose run badly out of control."^[1] The Independent was decidedly negative, writing "there could hardly be a neater illustration of O'Brien's fatal humourlessness, and of the extent to which too much posing as a tragedy queen has turned her deaf to her own bathetic effects."^[2]

Publishers Weekly was slightly more positive, noting that the scenes about McGreevy the terrorist were unsuccessful, but describing the novel on a whole as "Powerful, however, is the elegiac voice on themes of womanly love, the tale's psychological acuity and the re-creation of a haunted landscape."^[3] Kirkus Reviews describes it as successful, its "well worth reading as O'Brien's first concentrated treatment of the troubles--and the pain they visit on the Irish people."^[4]