Human fertilization

Human fertilization is the union of a human egg and sperm, occurring primarily in the ampulla of the fallopian tube.[1] The result of this union leads to the production of a fertilized egg called a zygote, initiating embryonic development. Scientists discovered the dynamics of human fertilization in the nineteenth century.[2]

Human fertilization
Sperm about to enter the ovum with acrosomal head ready to penetrate the zona pellucida and fertilize the egg
Illustration depicting ovulation and fertilization
Gives rise toZygote
Anatomical terminology

The process of fertilization involves a sperm fusing with an ovum. The most common sequence begins with ejaculation during copulation, follows with ovulation, and finishes with fertilization. Various exceptions to this sequence are possible, including artificial insemination, in vitro fertilization, external ejaculation without copulation, or copulation shortly after ovulation.[3][4] Upon encountering the secondary oocyte, the acrosome of the sperm produces enzymes which allow it to burrow through the outer shell called the zona pellucida of the egg. The sperm plasma then fuses with the egg's plasma membrane, triggering the sperm head to disconnect from its flagellum as the egg travels down the Fallopian tube to reach the uterus.

In vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the womb, in vitro.

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