Major highways

• U.S. Highway 49W
• Mississippi Highway 7
• Mississippi Highway 12
• Mississippi Highway 14
• Mississippi Highway 16

Adjacent counties

• Sunflower County (north)
• Leflore County (northeast)
• Holmes County (east)
• Yazoo County (south)
• Sharkey County (southwest)
• Washington County (west)

National protected area

• Theodore Roosevelt National Wildlife Refuge (part)
• Sky Lake Wildlife Management Area; the 3,500-acre (1,400 ha) area contains some of the oldest and largest bald cypress trees in the world.^[4]

2020 census

As of the 2020 United States Census, there were 7,785 people, 3,186 households, and 2,078 families residing in the county.

2010 census

As of the 2010 United States Census, there were 9,375 people living in the county: 74.5% were Black or African American, 23.5% White, 0.2% Asian, 0.1% Native American, 0.9% of some other race and 0.7% of two or more races, and 2.2% were Hispanic or Latino (of any race).

2000 census

At the 2000 census,^[12] there were 11,206 people, 3,765 households and 2,695 families living in the county. The population density was 27 per square mile (10/km²). There were 4,138 housing units at an average density of 10 per square mile (3.9/km²). The racial makeup of the county was 27.17% White, 71.51% Black or African-American, 0.10% Native American, 0.27% Asian, 0.64% from other races, and 0.31% from two or more races. 1.50% of the population were Hispanic or Latino of any race.

There were 3,765 households, of which 36.60% had children under the age of 18 living with them, 38.30% were married couples living together, 27.70% had a female householder with no husband present, and 28.40% were non-families. Of all households, 24.90% were made up of individuals, and 10.90% had someone living alone who was 65 years of age or older. The average household size was 2.95 and the average family size was 3.54.

Age distribution was 32.70% under the age of 18, 10.70% from 18 to 24, 25.80% from 25 to 44, 18.80% from 45 to 64, and 12.00% who were 65 years of age or older. The median age was 30 years. For every 100 females there were 87.50 males. For every 100 females age 18 and over, there were 78.70 males.

The median household income was $20,566, and the median family income was $23,719. Males had a median income of $24,948 versus $19,201 for females. The per capita income for the county was $10,926. About 32.40% of families and 38.20% of the population were below the poverty line, including 50.30% of those under age 18 and 31.00% of those age 65 or over.

Humphreys County has the seventh-lowest per capita income in Mississippi and the 56th-lowest in the United States.

In April 2019, Propublica identified Humphreys County as the county most intensely audited by the IRS.^[13]

City

• Belzoni (county seat)

Towns

• Isola
• Louise
• Silver City

Unincorporated communities

• Bellewood
• Deovolente
• Lodi
• Midnight