The second cabinet of Ion Ghica was the government of Romania from 15 July 1866 to 21 February 1867.

The ministers of the cabinet were as follows:^[1]

• President of the Council of Ministers:

• Ion Ghica (15 July 1866 - 21 February 1867)

• Minister of the Interior:

• Ion Ghica (15 July 1866 - 21 February 1867)

• Minister of Foreign Affairs:

• George B. Știrbei (15 July 1866 - 21 February 1867)

• Minister of Finance:

• Petre Mavrogheni (15 July 1866 - 21 February 1867)

• Minister of Justice:

• Ion C. Cantacuzino (15 July 1866 - 21 February 1867)

• Minister of War:

• Col. Ioan Gr. Ghica (15 July - 6 August 1866)
• Col. Nicolae Haralambie (6 August 1866 - 8 February 1867)
• Gen. Tobias Gherghely (8 - 21 February 1867)

• Minister of Religious Affairs:

• Constantin A. Rosetti (15 - 19 July 1866)
• Ion Strat (19 July 1866 - 21 February 1867)

• Minister of Public Works:

• Dimitrie A. Sturdza (15 July 1866 - 21 February 1867)