DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.^[5]

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ID2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AYA
Identifiers
Aliases	ID2, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
External IDs	OMIM: 600386 MGI: 96397 HomoloGene: 1632 GeneCards: ID2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 8,678,845 bp[1] End 8,684,461 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.3|12 8.57 cM Start 25,143,798 bp[2] End 25,147,139 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery saphenous vein pericardium right lobe of liver trachea lower lobe of lung renal medulla seminal vesicula vena cava urethra Top expressed in vas deferens seminal vesicula cerebellar vermis abdominal wall dermis left lung lobe hand parotid gland gallbladder adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity transmembrane transporter binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor binding Cellular component nucleus cytosol cytoplasm protein-containing complex Biological process regulation of G1/S transition of mitotic cell cycle rhythmic process negative regulation of DNA-binding transcription factor activity regulation of transcription, DNA-templated positive regulation of transcription involved in G1/S transition of mitotic cell cycle multicellular organism development negative regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II metanephros development natural killer cell differentiation thigmotaxis leukocyte differentiation membranous septum morphogenesis bundle of His development heart development circadian rhythm adult locomotory behavior entrainment of circadian clock positive regulation of gene expression negative regulation of gene expression oligodendrocyte development regulation of lipid metabolic process olfactory bulb development circadian regulation of gene expression mammary gland epithelial cell proliferation regulation of circadian rhythm entrainment of circadian clock by photoperiod enucleate erythrocyte differentiation negative regulation of DNA binding locomotor rhythm negative regulation of B cell differentiation positive regulation of fat cell differentiation positive regulation of erythrocyte differentiation positive regulation of macrophage differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of blood pressure positive regulation of transcription, DNA-templated cell development cell maturation Peyer's patch development embryonic digestive tract morphogenesis positive regulation of smooth muscle cell proliferation neuron fate commitment cell morphogenesis involved in neuron differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation adipose tissue development mammary gland alveolus development epithelial cell differentiation involved in mammary gland alveolus development endodermal digestive tract morphogenesis cellular response to lithium ion cellular senescence negative regulation of neural precursor cell proliferation neuron differentiation regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3398 15902 Ensembl ENSG00000115738 ENSMUSG00000020644 UniProt Q02363 P41136 RefSeq (mRNA) NM_002166 NM_010496 RefSeq (protein) NP_002157 NP_034626 Location (UCSC) Chr 2: 8.68 – 8.68 Mb Chr 12: 25.14 – 25.15 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene.^[6] The ID2 protein may play a role in the development and resistance to therapies of glioblastoma, the most aggressive of brain cancers.^[7]

ID2 has been shown to interact with MyoD^[8] and NEDD9.^[9]

• Inhibitor of DNA-binding protein