The Inland Empire 66ers of San Bernardino are a Minor League Baseball team of the California League and the Single-A affiliate of the Los Angeles Angels. The 66ers are based in San Bernardino, California, and play at San Manuel Stadium.

The 66ers began when the Salinas Spurs moved to San Bernardino and bought the name of the San Bernardino Spirit from the Rancho Cucamonga Quakes who had just left town. The team was bought by Elmore Sports Group soon afterwards. The team originally played at Fiscalini Field until 1996 when the team moved to San Bernardino Stadium, nicknamed "The Ranch" in concert with the team's new name, the San Bernardino Stampede.

Later, the stadium was re-christened San Manuel Stadium sponsored by the San Manuel Band of Mission Indians with their casino.

The team name was later changed to the team's current name, the Inland Empire 66ers, taken from the historic U. S. Route 66 that ran through San Bernardino.

In September 2006, the 66ers announced they were renewing its affiliation with the Los Angeles Dodgers beginning in the 2007 season. That affiliation would last through the end of the 2010 season.

In September 2010, the 66ers agreed to a two-year affiliation with the Los Angeles Angels to be the MLB club's minor league "High A" ball affiliate.

The team was once unique for having a National Public Radio affiliate, KVCR-FM, as the station that broadcast its games on radio. However, in 2008 the team changed its station to commercial talk station KCAA.

In conjunction with Major League Baseball's restructuring of Minor League Baseball in 2021, the 66ers were organized into the Low-A West.^[1] They retained their affiliation with the Angels.^[2] In 2022, the Low-A West became known as the California League, the name historically used by the regional circuit prior to the 2021 reorganization, and was reclassified as a Single-A circuit.^[3]

On March 27, 2024, the club announced that Diamond Baseball Holdings had acquired ownership of the club.^[4]

• The dance team performing on the field
• The team at Lake Elsinore Diamond in 2012
• San Manuel Stadium

• San Bernardino Spirit (1993–1995)
• San Bernardino Stampede (1996–2002)
• Inland Empire 66ers (2003–present)