Inositol-pentakisphosphate_2-kinase

Inositol-pentakisphosphate 2-kinase

Inositol-pentakisphosphate 2-kinase

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In enzymology, an inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate ADP + 1D-myo-inositol hexakisphosphate
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Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate, whereas its two products are ADP and 1D-myo-inositol hexakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase. Other names in common use include IP5 2-kinase, Gsl1p, Ipk1p, inositol polyphosphate kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, and Ins(1,3,4,5,6)P5 2-kinase.

References

    • York JD, Odom AR, Murphy R, Ives EB, Wente SR (1999). "A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export". Science. 285 (5424): 96–100. doi:10.1126/science.285.5424.96. PMID 10390371.
    • Phillippy BQ, Ullah AH, Ehrlich KC (1994). "Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 269 (45): 28393–9. PMID 7961779.
    • Phillippy BQ, Ullah AH, Ehrlich KC (1997). "Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 270 (13): 7782. doi:10.1074/jbc.270.13.7782.
    • Ongusaha PP, Hughes PJ, Davey J, Michell RH. "Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation". Biochem. J. 335: 671–9. PMC 1219831. PMID 9794810.
    • Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR (2004). "Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway". J. Biol. Chem. 279 (49): 51022–32. doi:10.1074/jbc.M409394200. PMID 15459192.
    • Stevenson-Paulik J, Odom AR, York JD (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277 (45): 42711–8. doi:10.1074/jbc.M209112200. PMID 12226109.


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