New Mexico state line to Pueblo

Following the Santa Fe Trail from New Mexico, I-25 enters Colorado while concurrent with US 85 and US 87. It is a typical four-lane Interstate Highway, and its entire route in Colorado lies close to the east side of the Rocky Mountains. The route turns from north to west-northwest as I-25 serves Wootton. After leaving Wootton, I-25 turns back up north and bypasses near the east side of the Trinidad Lake State Park, home of the Trinidad Lake.

Trinidad, a city near the Trinidad Lake, is the first major city that lies along I-25. For the next 30 miles (48 km), I-25 continues north through the rural areas of Colorado until it reaches the small city of Walsenburg, where State Highway 25C (Interstate 25 Business, I-25 Bus.) junctions with US 160. I-25 then continues in a north-northwest direction until it bypasses the Orlando Reservoir, then turns north from there until it reaches Colorado City. In Colorado City, I-25 interchanges with the east end of the Frontier Pathways Scenic and Historic Byway (SH 165) at exit 74.

After leaving the city, I-25 follows in a north-northeast orientation until it reaches the St. Charles Reservoir just before entering the city of Pueblo, with the first exit within the southern city limits of Pueblo at exit 94.^[5] The Arkansas River in Pueblo serves as a feeder to the Lake Pueblo State Park, home of Pueblo Lake, which is located to the west of the western city limits of Pueblo.^[6]

Pueblo to Denver

After leaving Pueblo, I-25 continues up north with the Union Pacific Railroad line paralleling closely to the route on the right side after interchanging with Porter Draw at exit 106. By exit 119, the Fountain Creek joins along and travels parallel with I-25, and continues all the way to the Fountain Creek Regional Park in Widefield. I-25 gradually turns from a general north direction to the north-northwest and serves the census-designated place of Buttes at exit 122.

As soon as US 85 leaves I-25 at exit 128, I-25 enters the city limits of Fountain. Basically, I-25 serves as the border between the western city limits of Fountain on the east side of I-25 and Fort Carson on the west side. Exit 132 (SH 16) serves the north side of the Fountain Creek Regional Park as well as the entrance to Fort Carson and connects to SH 21 (Powers Boulevard), the eastern bypass for the Colorado Springs metro area. By the time I-25 reaches exit 138, the route crosses into the city limits of Colorado Springs, where the stack interchange with US 24 at exit 139 serves the Evergreen Cemetery and Prospect Lake. I-25 turns west at exit 140, along with Fountain Creek, where it interchanges with US 85, US 87, and State Highway 25 Business (State Highway 25 Bus., I-25 Bus.). I-25, again, turns back north by exit 141. Swinging around the west side of downtown Colorado Springs at exit 142,^[5] and to the north of the city lies the Colorado College, and is served at exit 143 (Uintah Street). Continuing north and northeast, the highway intersects the north terminus of State Highway 25 Bus. and US 85. The Interstate leaves Colorado Springs between exits 153 and 156, where I-25 enters the United States Air Force Academy, going through the east side of the institution.

I-25 leaves El Paso County and enters Douglas County at Monument Hill, elevation 7,352 ft (2,241 m), north of Monument. I-25 then continues north through more rural and hilly areas east of the Rocky Mountains until reaching Castle Rock at exit 181. I-25 continues through rural and hilly portions of Douglas County until interchanging with E-470, the partial beltway of Denver as the toll road serves the Centennial Airport and the much larger Denver International Airport.

After entering Arapahoe County, I-25 cuts through the Denver Technological Center (DTC) between Dry Creek Road and Belleview Avenue (exits 196 and 199). I-25 enters Denver at the I-225 interchange, a spur that detours motorists to I-70 through Aurora, at exit 200. I-25 turns in a westerly direction between Evans Avenue (exit 203) and Colorado Boulevard (exit 204). University of Denver lies just to the south of the Interstate at exit 205. It then turns back north after exit 207. I-25 curves around the west side of downtown Denver,^[5] where it can be accessed by I-70 Bus. at exit 210.^[5] I-25 then interchanges with I-70 at exit 214 right before leaving the City and County of Denver.^[6]

Denver to Wyoming state line

As I-25 leaves Denver, the route continues up north through unincorporated areas of Adams County and interchanges with I-76, I-270, and the Denver-Boulder Turnpike (US 36). Due to the complexity of this triangle-shaped interchange, it was known to be one of many malfunction junctions throughout the United States. Beyond that interchange, the Interstate enters the northern suburbs of the Denver metro area, such as Thornton and Northglenn, and at exit 220, I-25 slips its way through a narrow path between the Badding Reservoir (west side) and the Croke Lake (east side). Development begins to drop off after exit 223 (120th Avenue) after continuing north into Westminster and eastern Broomfield.

At exit 228, I-25 interchanges with the northern terminuses of E-470 and Northwest Parkway at a stack interchange, with the Larkridge Mall just to the north, served by 160th Avenue (SH 7). As I-25 continues north, it moves through rolling farm and grasslands with the Front Range and high mountains clearly visible to the west while passing through a medley of lakes and reservoirs. It stays generally flat with few moderate climbs in elevation, while also serving smaller cities like Dacono and Firestone to the east and Longmont to the west. This stretch of I-25 in northern Colorado also has large amounts of truck traffic between SH 7 and Wyoming. After some time in the rural farmlands, the Interstate enters the Fort Collins–Loveland metro area at exit 255, serving Loveland and Greeley to at exits 255 and 257, Windsor at exit 262, and continuing north to the Fort Collins city limits south of Harmony Road. The highway runs on the eastern side of Fort Collins, serving Colorado State University at exits 268 and 269 (which is also the most direct route to downtown). After exit 271, I-25 leaves Fort Collins and rolls into more rural grasslands past Wellington. Exits also become few and far between from here to Wyoming as well after gradually turning north-easterly toward the state line.^[5][6]

Construction

Accidents and Incidents

In 1996, Seymour Cray was mortally wounded in a rollover accident while merging onto the highway at the North Academy Boulevard interchange. Cray's death renewed calls to replace the cloverleaf interchange with an alternative design without weave zones.^[12]

On October 11, 2023, a freight train derailed on a bridge over Interstate 25 in Pueblo, Colorado. As a result, several train cars fell onto the highway causing the bridge to collapse, 1 person was killed and 1 person was injured.^[13]

Auxiliary routes

In Colorado, I-25 has only one auxiliary route. Interstate 225 (I-225) is a 12-mile-long (19 km) spur route located within the Denver Metro Area. It runs from its parent highway from the Denver Tech Center to I-70 north of Aurora. It is an eastern bypass for travelers on I-25 looking to avoid Downtown Denver traffic and also provides direct connection to Denver International Airport for the southern suburbs of Denver. It is the only auxiliary route for I-25 as there are no other routes in Wyoming and New Mexico.

Business routes

Interstate 25 also has two active business routes within the state. In Aguilar, the town is connected to the freeway by Business Spur 25, which runs along Lynn Road and Walsenburg is served by Business Loop 25. There were three former routes that ran through Trinidad, Colorado Springs, and Castle Rock.