Isoconazole

Isoconazole

Isoconazole

Chemical compound

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.[1][2] For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.[3][4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.[1]

Quick Facts Clinical data, AHFS/Drugs.com ...

It was patented in 1968 and approved for medical use in 1979.[5]

References

  1. [1]
    Veraldi S (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 (Suppl 1): 3–15. doi:10.1111/myc.12054. PMID 23574019. S2CID 1881151.
  2. [2]
    Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (1996). "Isoconazole". In Budavari S (ed.). The Merck Index (12th ed.). p. 5176. ISBN 0-911910-12-3.
  3. [3]
    Oyeka CA, Gugnani HC (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–361. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811. S2CID 6764090.
  4. [4]
    Cohen L (February 1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". The British Journal of Venereal Diseases. 60 (1): 42–44. doi:10.1136/sti.60.1.42. PMC 1046268. PMID 6365236.
  5. [5]
    Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 502. ISBN 9783527607495.
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