Isometamidium_chloride

Isometamidium chloride

Isometamidium chloride

Chemical compound

Isometamidium chloride is a triazene trypanocidal agent used in veterinary medicine.[1][2]

Quick Facts Clinical data, ATCvet code ...

It consists of a single ethidium bromide like subunit linked to a fragment of the diminazene molecule.[citation needed]

Resistance

The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993.[3] This likely indicates a permanent loss of function in this area against the tested target, T. congolense isolated from Boran cattle.[3]

References

  1. [1]
    Whitelaw DD, Bell IR, Holmes PH, Moloo SK, Hirumi H, Urquhart GM, Murray M (June 1986). "Isometamidium chloride prophylaxis against Trypanosoma congolense challenge and the development of immune responses in Boran cattle". The Veterinary Record. 118 (26): 722–6. doi:10.1136/vr.118.26.722. PMID 3739193. S2CID 39168151.
  2. [2]
    Peregrine AS, Ogunyemi O, Whitelaw DD, Holmes PH, Moloo SK, Hirumi H, et al. (April 1988). "Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense". Veterinary Parasitology. 28 (1–2): 53–64. doi:10.1016/0304-4017(88)90018-0. PMID 3388736.
  3. [3]
    Mulugeta W, Wilkes J, Mulatu W, Majiwa PA, Masake R, Peregrine AS (April 1997). "Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia". Acta Tropica. 64 (3–4). Elsevier BV: 205–17. doi:10.1016/s0001-706x(96)00645-6. PMID 9107367. S2CID 23878484.
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