Isopentenyl_phosphate_kinase

Isopentenyl phosphate kinase

Isopentenyl phosphate kinase

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Isopentenyl phosphate kinase (EC 2.7.4.26) is an enzyme with systematic name ATP:isopentenyl phosphate phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

ATP + isopentenyl phosphate ADP + isopentenyl diphosphate

This enzyme takes part in the mevalonate pathway in Archaea.


References

  1. Grochowski LL, Xu H, White RH (May 2006). "Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate". Journal of Bacteriology. 188 (9): 3192–8. doi:10.1128/JB.188.9.3192-3198.2006. PMC 1447442. PMID 16621811.
  2. Lange BM, Croteau R (November 1999). "Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13714–9. doi:10.1073/pnas.96.24.13714. PMC 24130. PMID 10570138.
  3. Chen M, Poulter CD (January 2010). "Characterization of thermophilic archaeal isopentenyl phosphate kinases". Biochemistry. 49 (1): 207–17. doi:10.1021/bi9017957. PMC 3856865. PMID 19928876.
  4. Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD (May 2010). "X-ray structures of isopentenyl phosphate kinase". ACS Chemical Biology. 5 (5): 517–27. doi:10.1021/cb100032g. PMC 2879073. PMID 20402538.

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