Naturally occurring scandium (₂₁Sc) is composed of one stable isotope, ⁴⁵Sc. Twenty-five radioisotopes have been characterized, with the most stable being ⁴⁶Sc with a half-life of 83.8 days, ⁴⁷Sc with a half-life of 3.35 days, and ⁴⁸Sc with a half-life of 43.7 hours and ⁴⁴Sc with a half-life of 3.97 hours. All the remaining isotopes have half-lives that are less than four hours, and the majority of these have half-lives that are less than two minutes, the least stable being proton unbound ³⁹Sc with a half-life shorter than 300 nanoseconds. This element also has 13 meta states with the most stable being ^44m2Sc (t_1/2 58.6 h).

The isotopes of scandium range in atomic weight from 39 u (³⁹Sc) to 62 u (⁶²Sc). The primary decay mode at masses lower than the only stable isotope, ⁴⁵Sc, is beta-plus or electron capture, and the primary mode at masses above it is beta-minus. The primary decay products at atomic weights below ⁴⁵Sc are calcium isotopes and the primary products from higher atomic weights are titanium isotopes.