James Gladstone (Blackfoot: Akay-na-muka, lit. 'Many Guns';^[1] May 21, 1887 – September 4, 1971) was a Canadian politician who claimed to become the first Treaty Indian to be appointed to the Senate of Canada.

James Gladstone was of mixed racial ancestry. The future senator was not born First Nations and only became a status Indian at the age of 33, when in 1920 his wife's family petitioned the government for his inclusion on the Indian registry. His maternal grandfather, in fact, was a Scottish-Canadian, born in Montreal in 1832, who entered the service of the Hudson's Bay Company at the age of sixteen. While in the North-West Territories, William Shanks Gladstone^[1] married Harriet Leblanc, a Métis of Cree, Santee Sioux, and French Canadian heritage. One of their six children who survived to adulthood was Harriet (named after her mother), who was born at Rocky Mountain House in 1859. Harriet led a rough and unsteady life. After several years spent with a rough crowd of Métis and white frontiersmen, she formed a long-term relationship with a white lumber-mill foreman. Their union broke down, however, in the mid-1890s, and Harriet was left to raise skinny Jimmy, a boy with brown hair and blue eyes on her own. He was one of four children born to Harriet.

He attended St. Paul's Indian Residential School, because his Grandfather and local Anglican minister felt he would be fed, clothed, educated and spiritually looked after. He attended an Anglican mission school on the Blood reserve until 1903, when he moved to an Indian Industrial school (St Dunstans) in Calgary and apprenticed as a printer, interning at The Calgary Herald.^[2]

After leaving school in 1905, Gladstone returned to the Blood reserve where he worked as an interpreter. He also found work on ranches wrangling cattle. In 1911, he found work with the Royal North-West Mounted Police as a scout and interpreter and also worked as a mail carrier on the reserve. He is also reported as being a typesetter at one time at the Calgary Herald.^[1]

He was married to Blood member Janie Healy. After his marriage he was registered a member of the Blood reserve. Eventually, Gladstone established himself as a farmer and successful rancher^[1] (with 720 acres under cultivation and a herd of 400 Hereford cattle in 1958^[3]) and worked with his sons to assemble the 400 head of cattle and introducing modern farming practices to the reserve, including first use of a tractor in 1920.^[3]

In 1949, Gladstone was elected president of the Indian Association of Alberta though another source records his presidency as 1945–1954,^[3] and was sent to Ottawa three times to press for improvements to the Indian Act. His acceptance by both Blackfoot and Cree assisted him in bringing the different groups together in one political organization.

He was nominated to the Senate by Progressive Conservative Prime Minister John Diefenbaker in January 1958, at age 70,^[1] two years before status Indians gained the vote in federal elections, and he pressed for Aboriginals to be enfranchised. He sat as an "independent Conservative" "representing 160,000 Indians across the land."^[1] He advocated for integration into Canadian society. He was the chair of the Standing Committee on Indian Affairs. To meet the property qualifications for the Senate "he drove with his wife to nearby Cardston and paid cash for a five-room bungalow."^[3]

Gladstone retired from the Senate in March 1971 and died of a heart attack on September 4, 1971, in Fernie, British Columbia.^[4]

A biography of Senator Jim Gladstone, written by Alberta historian (and Gladstone's son-in-law) Hugh Dempsey, is entitled The Gentle Persuader.

In 2017, the Bank of Canada unveiled a commemorative Canadian ten-dollar note in honour of Canada 150, featuring Gladstone's portrait alongside Sir John A. Macdonald, Sir George-Étienne Cartier, and Agnes Macphail.^[5]