Cincinnati Bengals

On May 12, 2014, Wilder was signed as an undrafted free agent by the Cincinnati Bengals. On August 30, 2014, he was waived by the Bengals. He was signed to the Bengals' practice squad after clearing waivers. On January 14, 2015, Wilder signed a reserve/future contract with the Bengals. On September 5, 2015, he was waived by the Bengals.^[6] On the following day, he was signed to the Bengals' practice squad.^[7]

Buffalo Bills

On January 20, 2016, Wilder signed a reserve/future contract with the Buffalo Bills.^[8] On September 2, 2016, he was waived/injured by the Bills.^[9] He was then placed on injured reserve. He was released by the Bills on September 27, 2016.

Toronto Argonauts

Wilder signed with the Toronto Argonauts on March 14, 2017, reuniting head coach Marc Trestman with the family, as Trestman was a former Tampa Bay Buccaneers assistant coach when Wilder's father was a running back on the team.^[10] Following an injury to starting running back Brandon Whittaker, Wilder made his first professional start on July 24, 2017, against the Ottawa Redblacks.^[11] Wilder took over the starting running back role in September, earning consecutive player of week honors in weeks 13 and 14, gaining 257 and 218 yards from scrimmage in each game, respectively.^[12] He amassed 872 yards and 5 touchdowns on 122 carries, as well as 467 yards on 51 catches, and was named the CFL's Most Outstanding Rookie on November 23, 2017. While largely contained in both playoff games the Argonauts played in, Wilder rushed for a touchdown in the final game of the year, helping Toronto secure a Grey Cup championship.

In late January 2018 Wilder announced that he was planning to sit out of the Argos' 2018 season in the hopes of pursuing a return to the NFL in 2019.^[13] Wilder noted that his current contract of $56,000 (around US$45,000) in 2018, combined with the risk of career ending injury, does not give his family comfort about the future were he to play in 2018.^[14] The Argonauts issued a statement in response to Wilder's comments, stating their expectations of him to fulfill his contractual agreement with the organization. Failure to report to the team in due course will likely result in him being placed on the team's suspended list for his decision as per his contractual commitments with the organization.^[15] By February 27, 2018, the Argos had reportedly offered Wilder a contract extension which would make him one of the highest-paid running backs in the league.^[16] On March 3, 2018, the Argos and Wilder agreed to a two-year contract extension, keeping him in Toronto through the 2019 season.^[17] The deal is reportedly worth $100,000 per year, with no signing bonus.^[18] Wilder played in the first 13 games of the season for the Argos, before suffering a leg injury in Week 16.^[19]

Wilder, who began the 2019 season as the Argos' starting running back, was listed as a healthy-scratch by the Argos during the team's August 16, 2019 loss to the Eskimos: The loss pushed the Argos record to 1–7.^[20] He finished the 2019 season playing in 14 games, rushing 92 times for 464 yards and one touchdown and catching 47 passes for 415 receiving yards and four touchdowns.^[21] Prior to entering free agency, Wilder was released upon his request on November 25, 2019.^[21]

Montreal Alouettes

On January 30, 2020, Wilder signed a one-year contract with the Montreal Alouettes.^[22] It was a self-negotiated contract, reportedly for $90,000.^[23] In late June 2020, at age 28, due to uncertainty over the 2020 CFL season amid the COVID-19 pandemic, he announced his retirement from playing before being able to play a game with Montreal; he had already received a $25,000 signing bonus from his contract.^[24] He accepted a coaching position at his former high school in Tampa, Florida.^[25]

Edmonton Elks

On February 9, 2021, Wilder came out of retirement to sign a one-year contract with the Edmonton Elks.^[26] Wilder played in 12 games for the Elks in 2021, serving as the team's starting running back carrying the ball 142 times for 770 yards and two touchdowns. He also caught 28 passes for 226 yards and one receiving touchdown. On January 24, 2022, Wilder and the Elks agreed to a one-year contract extension.^[27] Wilder played in only three games during the 2022 season as his season was cut short by a neck injury which will require surgery in order to play professional football again.^[28] On March 29, 2023, the Elks released Wilder.^[29]