"Twenty Vicodin" is the eighth season premiere episode of the American television medical drama series House and the 156th overall episode of the series.^[4] It aired on Fox on October 3, 2011. The episode introduces a new regular cast member to the series, Odette Annable, who plays Dr. Jessica Adams.^[5] Jaleel White, who played Steve Urkel on the ABC show Family Matters, makes a guest appearance in the episode.^[6] In the episode, the storyline picks up eleven months after the season seventh finale with House in prison.^[7]

Eight months after being imprisoned for driving his car into Cuddy's living room, House has five days before he is granted parole, to which he has become eligible due to space issues and relatively good behavior. He is faced with prison bullies, mainly their leader (Jude Ciccolella), who extorts him into paying them "twenty Vicodin" as "exit tax", and meets Jessica Adams (Odette Annable), a young prison doctor who becomes fascinated with his medical skills. When a fellow prisoner collapses due to mysterious symptoms, House races against the clock and the head prison doctor to find the cure. During his imprisonment period, House has not had any phone calls or visitors; as House explains, human contact is what brought him there to begin with. In the end, House cures the man, but not without punishment from the parole board.^[8]

"Twenty Vicodin", the eighth season premiere of House, was written by Peter Blake.^[9] It debuted actress Odette Annable as Dr. Jessica Adams, a doctor working at the prison where Dr. House is incarcerated.^[5] David Shore stated that it was a challenge for him to appropriately punish House for the deed in the season 7 finale without turning the series into a prison show or changing House's characteristics (while changing the environment around him, i.e. removing Cuddy and "chilling" his relationship with Wilson), and that is why he decided to pick up the story eight months after House's incarceration.^[10]