Cleveland Indians

After graduating from the Puerto Rico Baseball Academy and High School, the Indians selected Colón in the 12th round of the 2009 MLB draft.^[1] He missed the 2010 season due to injury. He spent the next three seasons pitching for the Lake County Captains of the Single–A Midwest League and the Carolina Mudcats of the High–A Carolina League. He reached the Akron RubberDucks of the Double–A Eastern League in 2014.^[2]

In 2015, the Indians converted Colón from a starting pitcher into a relief pitcher.^[3] He spent the 2015 season with Akron and the Columbus Clippers of the Triple–A International League. A minor league free agent after the 2015 season, the Indians resigned Colón with a non-roster invitation to spring training in 2016.^[4] That offseason, Minor League Baseball announced Colón failed a test for a "drug of abuse" for the second time, and would be suspended for the first 50 games of the 2016 season.^[5]

The Indians purchased Colón's contract and added him to the 40-man roster on July 2, 2016. The Indians promoted Colón to the major leagues on July 7.^[6]

On July 1, 2017, Colón was suspended for the remainder of the 2017 season after testing positive for a banned substance.^[7] The Indians designated Colón for assignment on October 2, 2017, and outrighted him to the Triple-A Columbus Clippers on October 6, 2017. He elected free agency following the season on November 6.^[8]

St. Louis Cardinals

On February 19, 2018, Colón signed a minor league deal with the St. Louis Cardinals. ^[9] He was released on March 28, 2018.

Bravos de León

On June 22, 2018, Colón signed with the Bravos de León of the Mexican League. He became a free agent after the season.