John Hume DD (c.1703–26 June 1782) was an English bishop.

John Hume was the son of Rev. William Hume (1651-1714) of Milton, Devon, and his wife Jane Robertson (d. 1733).^[1][2] Hume matriculated at Merton College, Oxford on 31 March 1721, aged 15. He migrated to Corpus Christi College, Oxford, graduating B.A. 1724, M.A. 1727, B.D. & D.D. 1743.^[3]

He became a Canon of Westminster (28 June 1742 – 1748)^[4] and a Canon of St Paul's Cathedral (30 March 1748 – 1766).^[5]

He was rector of Barnes, London from 1749 to 1758; he was appointed Bishop of Bristol in 1756.^[6] In 1758 he became Bishop of Oxford and Dean of St Paul's, and in 1766 Bishop of Salisbury and ex officio Chancellor of the Order of the Garter.^[7]

He died on 26 June 1782 and was buried in Salisbury Cathedral on 6 July 1782.^[8] The monument was sculpted by William Osmond.^[9]

He married twice. His first wife Ann died in 1757 without children. His second wife, Lady Mary Hay (d.1805), youngest daughter of George Hay, 8th Earl of Kinnoull.^[10] By his second wife he had three daughters.