Academics

• John Lewis (computer scientist) (born 1963), American computer science educator and author
• John Lewis (headmaster) (born 1942), New Zealand headmaster of Eton College
• John Lewis (philosopher) (1889–1976), British Unitarian minister and Marxist philosopher
• John David Lewis (1955–2012), American political scientist, historian, and Objectivist scholar
• John S. Lewis (born 1941), American professor of planetary science at the University of Arizona's Lunar and Planetary Laboratory
• John T. Lewis (1932–2004), Welsh mathematical physicist
• John Wilson Lewis (1930–2017), American political scientist

Businesspeople

• John Lewis (brewer) (1713–1792), British brewer
• John Lewis (department store founder) (1836–1928), British draper and founder of the John Lewis department store
• John Spedan Lewis (1885–1963), British industrial democracy pioneer, founder of the John Lewis Partnership
• Sir John Lewis (businessman), British businessman, solicitor and charity executive
• John Allen Lewis (1819–1895), American newspaper editor

Clergy

• John Lewis (antiquarian) (1675–1747), English clergyman
• John Lewis (archbishop of Ontario) (1825–1901), Anglican bishop, archbishop and author in Canada
• John Lewis (archdeacon of Cheltenham) (born 1934), British Anglican priest
• John Lewis (archdeacon of Hereford) (1909–1984), Anglican priest
• John Lewis (archdeacon of North-West Europe) (1939–1994), Archdeacon of North West Europe from 1982 to 1993
• John Lewis (bishop of North Queensland) (1926–2015), Australian Anglican bishop
• John Lewis (dean of Llandaff) (1947-2019), Welsh Anglican priest
• John Lewis (dean of Ossory) (1717–1783), Dean of Ossory in Ireland from 1755 to 1783

Musicians

• John Lewis (electronic musician) (died 1984), Canadian-British electronic music composer
• John Lewis (pianist) (1920–2001), American jazz pianist and composer with the Modern Jazz Quartet
• John Lewis (singer) (born 1947), British singer and multi-instrumentalist known professionally as Jona Lewie

Politicians

Sportspeople

• John Lewis (cricketer) (1867–1939), Australian cricketer
• John Lewis (footballer, born 1881) (1881–1954), Welsh international football player
• John Lewis (footballer, born 1949), Australian rules footballer for Hawthorn
• John Lewis (footballer, born 1953), Australian rules footballer for Fitzroy
• John Lewis (footballer, born 1954), English football player for Orient
• John Lewis (footballer, born 1955), Welsh football player and manager
• John Lewis (referee) (1855–1926), English football player, administrator, referee and co-founder of Blackburn Rovers F.C.
• John Lewis (weightlifter) (born 1943), Canadian Olympic weightlifter
• John Goulstone Lewis (1859–1935), Welsh international rugby union player
• John Henry Lewis (1914–1974), American boxer and world light heavyweight champion
• Buddy Lewis (John Kelly Lewis, 1916–2011), American baseball player

Other people

• John Lewis (1678–1762), Virginia pioneer and father of General Andrew Lewis and Thomas Lewis
• John Lewis (criminal) (died 1910), American gangster from New York City, known as Spanish Louie
• John Lewis (journalist) (born 1933), Australian journalist
• John Lewis (Nebraska activist) (1841–?), hotelier, musician, and civil rights activist in Omaha, Nebraska
• John Lewis (typographer) (1912–1996), British typographer and illustrator
• John Frederick Lewis (1805–1876), English Orientalist painter
• John L. Lewis (1880–1969), American labor leader
• John P. Lewis (1921–2010), American academic and presidential advisor
• John Percy Leon Lewis (1943–2020), Guyanese military officer
• John Randolph Lewis (1834–1900), American dentist, soldier, administrator, and postmaster
• John Taylor Lewis (1894–1983), American army officer
• F. John Lewis, American surgeon