Jong PSV

Jordy de Wijs joined the PSV academy in 2005.^[4] In 2008, de Wijs won the title with the PSV D-juniors. In 2013, de Wijs was part of the under-19 team that came from two down to beat Feyenoord 3–2 to win the cup.^[5] He made his professional debut as Jong PSV player in the second division on 28 February 2014 against Almere City in a 3–1 away win playing the full game.^[6]

PSV

Throughout May 2014, de Wijs was part of the PSV squad that travelled to South Korea where Ji-Sung Park played his farewell matches.^[5] On 4 June 2014, de Wijs signed a new two-year contract with an option of a further year.^[5]

On 25 February 2015, de Wijs was called up for the trip to Saint Petersburg where PSV were to face Zenit in a Europa League round of 32 tie. PSV lost 3–0 on the day and 4–0 on aggregate and de Wijs was an unused substitute.^[7]

On 9 July 2015, de Wijs was named part of the senior squad that would fly to PSV's pre-season camp in Evians-les-Bains taking part in the Valais Cup.^[8] On 15 September 2015, de Wijs was an unused substitute in a 2–1 Champions League group win over Manchester United.^[9] On 21 October 2015, he made his senior debut in a Champions League game coming on as a substitute for Simon Poulsen in the 74th minute against Wolfsburg where they lost 2–0. Ten days later, de Wijs made his Eredivisie debut against De Graafschap replacing Héctor Moreno where they won 6–3.^[4][10] On 21 November 2015, de Wijs with teammate Jeroen Zoet signed new deals keeping them at the club until 2019.^[11] After impressing at Jong PSV, de Wijs was called up for the first-team by manager Phillip Cocu on 3 December 2015.^[12]

On 23 November 2016, de Wijs came on as a substitute at half-time replacing Jetro Willems in a Champions League match against Atlético Madrid where they lost 2–0.^[13]

Hull City

On 11 July 2018, de Wijs signed a three-year contract, with an option of a fourth year, with Hull City for an undisclosed fee.^[18] He made his debut in the first match of the 2018–19 season on 6 August 2018 at home to Aston Villa in a 3–1 defeat.^[19] He scored a late goal on 10 April 2019 at the KCOM Stadium against Wigan Athletic to secure a 2–1 win.^[20]

On 28 September 2019, de Wijs scored a header from a cross by Jarrod Bowen which was his first goal of the campaign in a 2–2 draw with Cardiff.^[21] His only other goal of the season was another header in a defeat against Bristol City which ended 2–1.^[22] On 17 June 2020, de Wijs was named as captain for rest of the restarted 2019–20 season after captain Eric Lichaj and vice-captain Jackson Irvine both turned down a short-term contract extension.^[23]

On 29 November 2020, de Wijs suffered a fractured eye socket in a FA Cup tie against Stevenage where they lost on penalties.^[24]

Queens Park Rangers

On 13 May 2021, following a successful loan spell, de Wijs signed permanently for Queens Park Rangers on a three-year deal.^[28]

Fortuna Düsseldorf

On 21 June 2022, de Wijs moved to Fortuna Düsseldorf on a permanent basis and signed a four-year contract with the club.^[30]