Jorge Calles-Escandon (born 11 November 1951) is a Mexican-American physician and researcher who practices at the MetroHealth Medical Center in Cleveland, Ohio. Calles-Escandon is a prominent endocrinologist,^[2] researcher, educator, and speaker.

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Calles-Escandon was born in Mexico City 1951, Mexico. He is the Director of the Center for Diabetes and Obesity of MetroHealth.

Calles-Escandon received a medical degree from the National Autonomous University of Mexico 1976.