José Francisco Ruiz Massieu (July 22, 1946 – September 28, 1994) was a Mexican political figure. He was governor of Guerrero from 1987 to 1993. He then served as the secretary-general of the Institutional Revolutionary Party (PRI) in 1994. His term ended with his assassination.

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José Francisco Ruiz Massieu, the brother-in-law of then-President of Mexico Carlos Salinas, was due to become the PRI majority leader in the Chamber of Deputies. That changed on the morning of September 28, 1994, when he was murdered by a gunman, 28-year-old Daniel Aguilar Treviño, just outside Hotel Casa Blanca, located at Lafragua street crossing Paseo de la Reforma, an avenue in the center of Mexico City. The incident occurred while Ruiz Massieu was boarding his vehicle after attending a PRI party meeting held at Casa Blanca.

His murder happened just six months after the murder of PRI party presidential candidate Luis Donaldo Colosio, who was gunned down on March 23, 1994, in Tijuana. Two days after the murder, on September 30, 1994, PRI deputy Fernando Rodríguez González was arrested in Zacatecas and confessed to authorities that he himself hired hitman Aguilar Treviño and his cousin to commit the murder. Daniel Aguilar Treviño confessed to authorities that he was paid US$500,000 (equivalent to $1,028,000 in 2023) by Rodríguez González himself to commit the crime.

In October 2017, a judge in Mexico City decided to reduce Aguilar Treviño’s sentence from the original 50 years down to 42, now set to be released in 2036.

When Rodríguez González was interrogated, he then revealed that PRI Deputy Manuel Muñoz Rocha was involved in the planning of the murder.^{[citation needed]} Muñoz Rocha, who disappeared just days after the murder, made a phone call to a Mexico City television station saying that he was willing to come forward and give his side of the story to PGR authorities if his request for protection was met. Such request was approved by government officials, but, by then, Muñoz Rocha was never to be seen or heard of again. Two weeks later, the assistant attorney general investigating the case, Mario Ruiz Massieu, the brother of the assassinated politician, resigned because of irregularities from PRI officials in the case. He claimed he had proof of PRI party president Ignacio Pichardo Pagaza and party secretary María de los Ángeles Moreno hiding evidence and thus blocking the investigation. Pichardo Pagaza and Moreno requested for proof to be shown, but it was never found.

Jorge Rodríguez Gónzalez who was originally sentenced to 50 years for his involvement in the murder had his sentence reduced down to 37 years (now set to be released in 2041). Then in 2018, a federal judge granted Rodríguez Gónzalez parole. However, Rodríguez Gónzalez was later denied the parole after failing to pay the needed bail amount.