Seleucus (fl. c. 221) was a Roman usurper.

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Seleucus was, according to the 5th-century historian Polemius Silvius, a usurper against Emperor Elagabalus. His identity is not known: he could be Julius Antonius Seleucus, governor in Moesia, or Marcus Flavius Vitellius Seleucus, consul for 221.

• Peacock, Phoebe, "Seleucus", s.v. "Usurpers under Elagabalus", De Imperatoribus Romanis