Khaled Holmes (born January 19, 1990) is a former American football center. He played college football at USC, and was drafted by the Indianapolis Colts in the fourth round of the 2013 NFL Draft.

Holmes was born in San Diego, California. As a senior offensive lineman at Mater Dei High School in Santa Ana, he was named a Prep Star All American. Trojan teammates Matt Barkley, Victor Blackwell and Max Wittek also prepped at Mater Dei in 2007.

Holmes enrolled in the University of Southern California, where he played for the USC Trojans football team from 2009 to 2012. He started all of 2010 at right offensive guard as a sophomore and was named a 2010 All-Pac-10 honorable mention. Holmes started for his second season on the offensive lineman as a junior in 2011, performing exceptionally well at center in 2011 after playing offensive guard in 2010. He made the 2011 All-Pac-12 second-team and the Phil Steele All-Pac-12 second-team. He was moved from guard to center in 2011 spring practice. Holmes received his bachelor's degree in Classics at USC in the spring of 2011 and completed a master's degree in Communication Management the following year, 2012. He made the 2011 Pac-12 All-Academic second-team. He made 2010 Pac-10 All-Academic honorable mention. Holmes started his third season as a senior in 2012 as an Academic All-American candidate and after the regular season was named one of six finalists for the Rimington Trophy, given annually to college football's top center.^[1]

Holmes was considered one of the top interior line prospects in the 2013 NFL Draft.^[2]