Academic and scholarly activities

In 1953, while still a medical resident he published work supporting the association of asbestos exposure and cancer of the lung.^[5] While at the NIH, he discovered the enzymatic defect causing the hereditary disorder of galactosemia.^[6] This work led to the development of a test for this disorder which is now being used in routine screening of newborns. In addition, he elucidated the enzymatic mechanism for the formation of glucuronide conjugates, important for the detoxification of many compounds by the liver.^[7]

After returning from the NIH in 1956, at the age of 31 he was chosen to head the Gastrointestinal Unit at the MGH.^[3][8] Over the subsequent 30 years, his division became one of the leading centers of training, research and treatment of gastrointestinal diseases in the United States.^[3][8] His research during this period included the description and elucidation of a new hereditary disorder of leucine metabolism called isovaleric acidemia,^[9] the definition of enzymatic defects in absorptive disorders, delineations of biochemical mechanism of nutrient absorption,^[10] malabsorption,^[11] and protein synthesis, derangements of metabolism and immunologic aspects of hepatic gastrointestinal diseases.^[3]

In 1987, he undertook the challenge of becoming the first director of the Massachusetts General Hospital Cancer Center, and in a relatively short period of time that Center emerged as a "premier" cancer research institute."^[3] He became director emeritus in 2003. For almost 30 years, (1966-1995) he served as chairman of the executive committee of Harvard's Departments of Medicine and played a pivotal role in the departments' growth and quest for excellence.^[8] Dr. Isselbacher trained over 140 clinical and research fellows both in gastroenterology and oncology and many of them have become leaders in their respective fields nationally and internationally. His publications included close to 400 journal articles and book chapters.

He served on the editorial boards of Journal of Clinical Investigation (1962-1972) and Gastorenterology (1963-1968) and was also consulting editor of Medicine (1962-1994). His leadership in medicine was also recognized nationally and internationally by virtue of his role as an editor of Harrison's Principles of Internal Medicine.^[8] This book is viewed by many as the leading text in internal medicine. It is used worldwide and has been translated into 18 languages. Dr. Isselbacher was a member and officer in many professional associations, including the National Academy of Sciences (NAS), the National Research Council, the American Academy of Arts and Sciences, and the Institute of Medicine. He served as president of the American Gastroenterological Association, the American Association for Study of Liver Diseases, and the Association of American Physicians. He also served as a member of the Science Advisory Board of the Food and Drug Administration. Dr. Isselbacher received many awards and honors including the Distinguished Achievement Award and the Friedenwald Medal of the American Gastroenterological Association, the John Phillips Memorial Award for Distinguished Achievement in Clinical Medicine, and from Squibb/Mead Johnson the Award for Distinguished Achievement in Nutrition Research. In 2001, he received the Kober Medal of the Association of American Physicians,^[12] which is the highest recognition that this Association can bestow on one of its members and also an honorary Doctor of Science degree from Northwestern University.