In enzymology, a L-arabinitol 4-dehydrogenase (EC 1.1.1.12) is an enzyme that catalyzes the chemical reaction

L-arabinitol + NAD⁺ ${\displaystyle \rightleftharpoons }$ L-xylulose + NADH + H⁺

Thus, the two substrates of this enzyme are L-arabinitol and NAD⁺, whereas its 3 products are L-xylulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-arabinitol:NAD⁺ 4-oxidoreductase (L-xylulose-forming). Other names in common use include pentitol-DPN dehydrogenase, and L-arabitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.