In enzymology, a L-pipecolate dehydrogenase (EC 1.5.99.3) is an enzyme that catalyzes the chemical reaction

L-pipecolate + acceptor ${\displaystyle \rightleftharpoons }$ 2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are L-pipecolate and acceptor, whereas its two products are 2,3,4,5-tetrahydropyridine-2-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is L-pipecolate:acceptor 1,6-oxidoreductase. This enzyme is also called L-pipecolate:(acceptor) 1,6-oxidoreductase. This enzyme participates in lysine degradation.