Lake Centre was a federal electoral district in Saskatchewan, Canada, that was represented in the House of Commons of Canada from 1935 to 1953. This riding was created in 1933 from parts of the ridings of Last Mountain, Long Lake and Regina.

From 1940 to 1953, the riding's Member of Parliament was John Diefenbaker, who later served as Prime Minister of Canada from 1957 to 1963 (though he was the member for Prince Albert by then).

It was abolished in 1952 when it was redistributed into Melville, Moose Jaw—Lake Centre, Rosetown—Biggar and Yorkton ridings.

• List of Canadian federal electoral districts
• Historical federal electoral districts of Canada

• Riding history for Lake Centre (1933–1952) from the Library of Parliament