Main characters

• Lil' George (George W. Bush), voiced by Chris Parson; the leader of the gang, he often makes choices without thinking about the consequences and is seldom corrected by his friends. Like the real George W. Bush, he enjoys giving people various nicknames. He has a crush on the series' caricature Laura Bush, refers to her as a "chubby nerd". Additionally, though the show is entitled Lil Bush, the character himself is always referred to by the other characters (and in the scripts) as Lil' George.
• George Sr. (George H. W. Bush), voiced by Dave B. Mitchell; the President of the United States who acts as somewhat of a straight man to Lil' George. He is shown to be extremely weak physically, and possessing a deep love for Saltine crackers. He and Barbara are also swingers and although he loves his wife, he has a specific time scheduled at work for "old people sex" with his secretary. He is also seen to be allergic to people who look Asian as seen in the 'Hall Monitor' episode (a reference to when Bush threw up onto the lap of Japan's Prime Minister).
• Barbara Bush, voiced by Mara Cary; the sexually frustrated wife of the President, so much so that she once resorts to having a tryst with Lil' Cheney. She has also admitted to having an affair with Michael Dukakis. She was confused with a polar bear in "Gay Friend". According to George Sr., Barbara Bush was a "Frankenstein of presidential parts" added with woman parts that he brought to life, giving her the head of George Washington.
• Jeb Bush, voiced by Dave B. Mitchell; the indestructible but mentally undeveloped brother to Lil' George. His family shows a general apathy towards his well-being. This could possibly be because he is able to withstand things that would kill an ordinary person, and sometimes benefits from them. In one episode, Jeb withstands a nuclear blast, and in another, climbs onto a missile about to be fired, but appears completely unharmed. When Jeb is hit in the head with a frying pan, he speaks normally (then voiced by Colin Meloy) and openly criticizes his father's governmental decisions. Jeb is treated like a pet, as he is taken for walks, given flea dips, and eats from a bowl with his name on it (often next to the actual family dog Barney).
• Lil' Cheney (Dick Cheney), voiced by Donick Cary; a friend of Lil' George, he growls incoherently rather than speaking, with the occasional interjection of a contextually relevant word or phrase, (saying "reh-reh-REH-massive heart attack-reh-reh-REH," for instance); the rest of the characters appear to understand him. He has deranged and violent tendencies, such as consuming raw—sometimes living—meat and blood.
• Lil' Condi (Condoleezza Rice), voiced by Ann Villella in Season 1 and Kari Wahlgren in Season 2 , acts as the voice of reason for her friends, though they routinely ignore her sensible advice. She has a crush on Lil' George, and attempts to woo him in various ways throughout the series, such as doing his homework for him and gaining an abundance of weight.
• Lil' Rummy (Donald Rumsfeld), voiced by Iggy Pop; seems to be the only remotely intelligent character on the show aside from Lil' Condi. He also displays a sadistic side, possibly resulting from the fact that he is abused by his father. He is sometimes used as a scapegoat, such as when George Sr. says one way to cover up a scandal is to blame it on Lil' Rummy.

Lil' Democrats

The series antagonists (also called Lil' Dems).

• Lil' Hillary (Hillary Clinton): voiced by Kari Wahlgren (in season 2) ; girlfriend of Lil' Bill, she works at an abortion clinic after school "just for fun" and is also suggested to be bisexual after kissing Lil' Condi.
• Lil' Barack Obama: voiced by Tim Meadows; shown laughing at Lil' George, he is "nuked" by Lil' George when he is seen sneaking a cigarette outside of the White House. He also leads Lil' George's friends after Lil' Bush abandons them for Lil' Tony Blair. He attempts to enlist their help in building a "Home for Humanity" for a single mother, but the gang burns it down (assuming that the plan was to commit insurance fraud or turn it into a dungeon and force single mothers to fight to the death) and use the money to buy themselves scooters. He frequently says "Yes we can" to answer questions.
• Lil' Al Gore: voiced by Chris Parson; always encouraging others to be eco-friendly and shown with an extremely eco-friendly house with many inventions created by Lil' Al himself (including a time machine, and an interconnected series of ropes which create a net that "catches dreams", he calls the "internet"). Lil' Bush constantly ridicules him for being slightly overweight (to make everyone else think so) despite the fact that Lil' George is shown to have more bodyweight than Lil' Al.
• Lil' Nancy Pelosi: shown sewing a flag with rainbow-colored stripes, she is also "nuked" by Lil' George. Voiced by production assistant Martha Cary, who is the show creator's half-sister.
• Lil' John Kerry: voiced by Chris Parson, Lil' Kerry's voice bores Lil' Bush and the gang. He loves ketchup, and says that someday he might marry it, in reference to his real-world marriage to condiment heiress Teresa Heinz Kerry.
• Lil' John Edwards: apparently obsessed with hair in reference to Edwards' $400 haircuts.
• Lil' Bill (Bill Clinton): voiced by Chris Parson; constantly cheats on Lil' Hillary.
• Tiny Kucinich: who wants to someday fly with doves. Sometimes has to be handled like an infant. Voiced by Jason Nash, who does a variety of other voices for the show.

Season 1 (2007-08)

Season 2 (2008)