Liquefaction of gases is physical conversion of a gas into a liquid state (condensation). The liquefaction of gases is a complicated process that uses various compressions and expansions to achieve high pressures and very low temperatures, using, for example, turboexpanders.

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Liquefaction processes are used for scientific, industrial and commercial purposes. Many gases can be put into a liquid state at normal atmospheric pressure by simple cooling; a few, such as carbon dioxide, require pressurization as well. Liquefaction is used for analyzing the fundamental properties of gas molecules (intermolecular forces), or for the storage of gases, for example: LPG, and in refrigeration and air conditioning. There the gas is liquefied in the condenser, where the heat of vaporization is released, and evaporated in the evaporator, where the heat of vaporization is absorbed. Ammonia was the first such refrigerant, and is still in widespread use in industrial refrigeration, but it has largely been replaced by compounds derived from petroleum and halogens in residential and commercial applications.

Liquid oxygen is provided to hospitals for conversion to gas for patients with breathing problems, and liquid nitrogen is used in the medical field for cryosurgery, by inseminators to freeze semen, and by field and lab scientists to preserve samples. Liquefied chlorine is transported for eventual solution in water, after which it is used for water purification, sanitation of industrial waste, sewage and swimming pools, bleaching of pulp and textiles and manufacture of carbon tetrachloride, glycol and numerous other organic compounds as well as phosgene gas.

Liquefaction of helium (⁴He) with the precooled Hampson–Linde cycle led to a Nobel Prize for Heike Kamerlingh Onnes in 1913. At ambient pressure the boiling point of liquefied helium is 4.22 K (−268.93 °C). Below 2.17 K liquid ⁴He becomes a superfluid (Nobel Prize 1978, Pyotr Kapitsa) and shows characteristic properties such as heat conduction through second sound, zero viscosity and the fountain effect among others.

The liquefaction of air is used to obtain nitrogen, oxygen, and argon and other atmospheric noble gases by separating the air components by fractional distillation in a cryogenic air separation unit.